PubMed Abstract PMID: 11036827
This abstract also posted in the files section of the K9Kitchen discussion group.
Monica's Comments
This study found that fish oil supplementation improved the clinical status of patients with rheumatoid arthritis, but the authors were not specific about the physical improvements of the patients. Rather, they gathered information on the presences of good acids and lipids in the bloodstream.
The authors used a dosage of 40 mg of fish oil for each kg of body weight, per day, using a fish oil containing 60% EFAs.
The Abstract
OBJECTIVE
To determine the efficacy of fish oil derived (n-3) fatty acid supplementation (3-6 capsules/day) in subjects with rheumatoid arthritis (RA) whose (n-6) fatty acid intake in the background diet was < 10 g/day, compared to olive/corn oil capsule supplement over a 15 week period.
METHODS
A placebo controlled, double blind, randomized 15 week study to determine the effect of supplementation on clinical variables in 50 subjects with RA whose background diet was naturally low in (n-6) fatty acids. Fish oil containing 60% (n-3) fatty acids was supplemented at a rate of 40 mg/kg body weight.
RESULTS
Analysis of 9 clinical variables indicated there was a significant difference (p < 0.02) between control and treatment groups. Five subjects in the treatment group and 3 in the control group met the American College of Rheumatology 20% improvement criteria. Dietary supplementation resulted in a significant increase in eicosapentaenoic acid in plasma and monocyte lipids in the supplemented group.
CONCLUSION
The findings suggest that fish oil supplementation that delivers (n-3) fatty acids at a dose of 40 mg/kg body weight/day, with dietary (n-6) fatty acid intake < 10 g/day in the background diet, results in substantial cellular incorporation of (n-3) fatty acids and improvements in clinical status in patients with RA.
Study Authors
Volker D, Fitzgerald P, Major G, Garg M.
Discipline of Nutrition and Dietetics, Faculty of Medicine and Health Sciences, and the Centre for Clinical Epidemiology and Biostatistics, University of Newcastle, Callaghan, NSW, Australia.
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